True/False True or False? A clinical trial is conducted to compare an experi

babeeb0oL

babeeb0oL

Answered question

2021-10-22

True/False
True or False? A clinical trial is conducted to compare an experimental medication to placebo to reduce the symptoms of asthma. One hundred participants are enrolled in the study and randomized to receive either the experimental medication or placebo. The primary outcome is self-reported reduction of symptoms. Among 50 participants who receive the experimental medication, 30 report a reduction of symptoms as compared to 15 participants of 50 assigned to the placebo. The 95% CI for the relative risk of participants reporting a reduction of symptoms between the experimental and placebo groups is between 1.529 and 8.012.

Answer & Explanation

2k1enyvp

2k1enyvp

Skilled2021-10-23Added 94 answers

"The 95% CI for the relative risk of participants reporting a reduction of symptoms between the experimental and placebo groups is between 1.529 and 8.012."
Given:
n1=50
n2=50
p^1=X1n1
=3050=0.6
p^2=X2n2
=1550=0.3
Calculating the relative risk (RR):
R=p^1p^2
=0.60.3
=2
Creating the 95% confidence interval for the log of relative risk is:
ln(R)±Zα2=0.025n1x1x1n1+n2x2x2n2
ln(2)±1.96×203050+151550
(0.213,1.173)
The 95% confidence interval for the relative risk hence is the antilog of the above values:
(1.237, 3.232)
Hence the answer is FALSE.

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